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CNS & Neurological Disorders - Drug Targets

Editor-in-Chief

ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

Targeting Epigenetics in Nervous System Disease

Author(s): Ruihan Zhang, Junyan Lu, Xiangqian Kong, Lu Jin and Cheng Luo

Volume 12 , Issue 1 , 2013

Page: [126 - 141] Pages: 16

DOI: 10.2174/1871527311312010018

Price: $65

Abstract

Epigenetics is key to understanding modulation of gene expression at specific stages and conditions in nervous system development and function. In epigenetic processes, a variety of enzymes contribute to modify chromatin with methyl, acetyl or other chemical marks, leading to repression or activation of the targeted gene without altering the original sequence. Aberrant activities of these epigenetic enzymes are implicated in many nervous system diseases, including neurodevelopmental disorders, brain cancer, neurodegenerative diseases, and mental illnesses. Thus, they have emerged as new targets for treating a variety of nervous system disorders. In this review, we briefly summarize the association between various epigenetic mechanisms and discuss recent progress in drug discovery efforts involving epigenetic regulators.

Keywords: DNA methyltransferase, epigenetics, glioma, histone deacetylase, histone methyltransferase, nervous system disease, neurodevelopmental disease, neurodegenerative disease


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