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Current Metabolomics


ISSN (Print): 2213-235X
ISSN (Online): 2213-2368

muma, An R Package for Metabolomics Univariate and Multivariate Statistical Analysis

Author(s): Edoardo Gaude, Francesca Chignola, Dimitrios Spiliotopoulos, Andrea Spitaleri, Michela Ghitti, Jose M Garcia-Manteiga, Silvia Mari and Giovanna Musco

Volume 1 , Issue 2 , 2013

Page: [180 - 189] Pages: 10

DOI: 10.2174/2213235X11301020005


Metabolomics, similarly to other high-throughput “-omics” techniques, generates large arrays of data, whose analysis and interpretation can be difficult and not always straightforward. Several software for the detailed metabolomics statistical analysis are available, however there is a lack of simple protocols guiding the user through a standard statistical analysis of the data.

Herein we present “muma”, an R package providing a simple step-wise pipeline for metabolomics univariate and multivariate statistical analyses. Based on published statistical algorithms and techniques, muma provides user-friendly tools for the whole process of data analysis, ranging from data imputation and preprocessing, to dataset exploration, to data interpretation through unsupervised/supervised multivariate and/or univariate techniques. Of note, specific tools and graphics aiding the explanation of statistical outcomes have been developed. Finally, a section dedicated to metabolomics data interpretation has been implemented, providing specific techniques for molecular assignments and biochemical interpretation of metabolic patterns.

muma is a free, user-friendly and versatile tool suite tailored to assist the user in the interpretation of metabolomics data in the identification of biomarkers and in the analysis of metabolic patterns.

Keywords: Chemometrics, metabonomics, metabolic pattern, multivariate analysis, R package, statistical analysis, univariate analysis.

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