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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Microwave-assisted Suzuki-Miyaura Cross-Coupling of Free (NH) 3-Bromoindazoles

Author(s): Ali Ben-Yahia, Mohammed Naas, Nabil El Brahmi, Said El Kazzouli, Jean-Pierre Majoral, El Mokhtar Essassi and Gerald Guillaumet

Volume 17, Issue 3, 2013

Page: [304 - 309] Pages: 6

DOI: 10.2174/1385272811317030011

Price: $65

Abstract

Suzuki-Miyaura cross-coupling of free (NH) indazoles is described. The reactions are carried out under microwave irradiation using various 3-bromoindazoles and boronic acids. Different reaction conditions were investigated and the best results were obtained using Pd(PPh3)4 and Cs2CO3 in a mixture of 1,4-dioxane/EtOH/H2O at 140 °C under microwave irradiation.

Keywords: Suzuki-Miyaura cross-coupling, Free (NH) indazoles, Microwave irradiation, Palladium-mediated cross-coupling, Boronic acids, Sealed vessel, 3-chloroindazole, Indazoles, Cs2CO3, Pyridin-3-ylboronic acid


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