Microwave-assisted Suzuki-Miyaura Cross-Coupling of Free (NH) 3-Bromoindazoles

Ali      Ben-Yahia; Mohammed      Naas; Nabil      El Brahmi; Said      El Kazzouli; Jean-Pierre      Majoral; El      Mokhtar Essassi; Gerald      Guillaumet

Abstract

Suzuki-Miyaura cross-coupling of free (NH) indazoles is described. The reactions are carried out under microwave irradiation using various 3-bromoindazoles and boronic acids. Different reaction conditions were investigated and the best results were obtained using Pd(PPh3)4 and Cs2CO3 in a mixture of 1,4-dioxane/EtOH/H2O at 140 °C under microwave irradiation.

Keywords: Suzuki-Miyaura cross-coupling, Free (NH) indazoles, Microwave irradiation, Palladium-mediated cross-coupling, Boronic acids, Sealed vessel, 3-chloroindazole, Indazoles, Cs2CO3, Pyridin-3-ylboronic acid

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Current Organic Chemistry

Title:Microwave-assisted Suzuki-Miyaura Cross-Coupling of Free (NH) 3-Bromoindazoles

Volume: 17 Issue: 3

Author(s): Ali Ben-Yahia, Mohammed Naas, Nabil El Brahmi, Said El Kazzouli, Jean-Pierre Majoral, El Mokhtar Essassi and Gerald Guillaumet

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Abstract: Suzuki-Miyaura cross-coupling of free (NH) indazoles is described. The reactions are carried out under microwave irradiation using various 3-bromoindazoles and boronic acids. Different reaction conditions were investigated and the best results were obtained using Pd(PPh3)4 and Cs2CO3 in a mixture of 1,4-dioxane/EtOH/H2O at 140 °C under microwave irradiation.

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Ben-Yahia Ali, Naas Mohammed, El Brahmi Nabil, El Kazzouli Said, Majoral Jean-Pierre, Mokhtar Essassi El and Guillaumet Gerald, Microwave-assisted Suzuki-Miyaura Cross-Coupling of Free (NH) 3-Bromoindazoles, Current Organic Chemistry 2013; 17(3) . https://dx.doi.org/10.2174/1385272811317030011