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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Synthesis and QSAR Modeling of Novel Benzimidazolo Thiazolidinones, Thiazinones and 5-arylidene-2-imino Thiazolidinones as Antibacterial Agents

Author(s): Manjunath Ghate, Praveena Devi, Jignesh Parikh and Vivek K. Vyas

Volume 9, Issue 3, 2013

Page: [474 - 485] Pages: 12

DOI: 10.2174/1573406411309030017

Price: $65


A novel series of benzimidazolo thiazolidinones, thiazinones and 5-arylidene-2-imino thiazolidinones were synthesized and evaluated for antibacterial activity. The compounds were synthesized in excellent yield and the structures were characterized on the basis of IR, 1H-NMR and MASS spectral data. Most of the synthesized compounds showed good antibacterial activity against Gram-positive and Gram-negative bacteria. QSAR study was carried out with synthesized compounds using molecular descriptors such as electronic, thermodynamic and steric. Molecular descriptors were used to derive QSAR models between antibacterial activity and structural properties. QSAR study suggested the need of a bulky group to enhance the antibacterial activity in these series of compounds.

Keywords: Antibacterial, Benzimidazole, QSAR, Thiazolidinone, Thiazinone, Iminothiazolidinone, 1H-NMR, QSAR, thiazolidin-4-one, schiff bases

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