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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Synthesis, Antifungal Evaluation and Molecular Docking Studies on 2- thioxoimidazolidin-4-one Derivatives

Author(s): Sudha Vengurlekar, Rajesh Sharma and Piyush Trivedi

Volume 9, Issue 3, 2013

Page: [459 - 473] Pages: 15

DOI: 10.2174/1573406411309030016

Price: $65


A series of 2-thioxo-imidazolidin-4-one derivatives were synthesized and were characterized by IR, 1H NMR, 13C NMR, mass spectral data and elemental analysis. All compounds were tested for antifungal and antibacterial activity. Some of the compounds were found to exhibit promising antifungal activity. Molecular modeling investigations showed that the active compounds may interact at the active site of the fungal cytochrome P450- dependent sterol 14α- demethylase in the sterol biosynthesis pathway.

Keywords: 2-thioxo-imidazolidin-4-one, antifungal, antibacterial, molecular modeling, Aspergillus fumigatus, Candida tropicalis, ketoconazole, C. albicans, acetic acid, sterol

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