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Current Psychiatry Reviews

Editor-in-Chief

ISSN (Print): 1573-4005
ISSN (Online): 1875-6441

Fragile X Syndrome: Psychiatric Manifestations, Assessment and Emerging Therapies

Author(s): Paula M. Wadell, Randi J. Hagerman and David R. Hessl

Volume 9 , Issue 1 , 2013

Page: [53 - 58] Pages: 6

DOI: 10.2174/157340013805289644

Price: $65

Abstract

Fragile X Syndrome (FXS), the most common inherited cause of intellectual disabilities, is an X-linked dominant disorder caused by the amplification of a CGG repeat in the 5' untranslated region of the fragile X mental retardation gene 1 (FMR1). Prevalence estimates of the disorder are approximately 1/3600. Psychiatric manifestations of the disorder include anxiety, attention deficit hyperactivity disorder, autism, mood instability and aggression. In this article we review the above psychiatric manifestations and challenges to accurate assessment. We also discuss how the neurobiological underpinnings of these symptoms are beginning to be understood and can help guide treatment.

Keywords: Assessment, Fragile X syndrome, Neurobiology, Psychiatric symptoms, Treatment


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