Abstract
The potential of flavonoids to act as anti-tumor agents has been recognized but not fully understood because flavonoids are acting at several stages in cancer progression with distinct structure-function relationships. A whole family of structurally different flavonoids is herein described by reviewing some critical aspects of their pro-oxidant behavior in vitro/vivo and in cell systems by which they may work as antioxidants. Different classes of flavonoids (chalcones, flavones, isoflavones, flavanols, flavanones and anthocyanins) are synthetically mimicked using natural product structure-antioxidant activity relationships that are relevant for their enhanced function against cancer as well as severe inflammation conditions under which an increased oxidative stress is often implicated. In the context of the common mechanisms of flavonoid action, clinical data on benefits of flavonoids in fighting against cancer are discussed. A structural basis needed to improve antioxidant activity of these agents is elaborated in more detail.
Keywords: Action, Anthocyanin, Anti-cancer agent, Antioxidant, Anti-tumor activity, Cell line, Chalcone, Clinical data, Cytotoxic activity, Flavone, Flavonoid, Flavanol, Flavanone, Flavopiridol, Function, Isoflavone, Mechanism, Quercetin, SAR, Structure
Anti-Cancer Agents in Medicinal Chemistry
Title:Experimental and Theoretical Advances in Functional Understanding of Flavonoids as Anti-Tumor Agents
Volume: 13 Issue: 2
Author(s): Bandarugattu V. Babu, Naveen K. Konduru, Waro Nakanishi, Satoko Hayashi, Naseem Ahmed and Petar M. Mitrasinovic
Affiliation:
Keywords: Action, Anthocyanin, Anti-cancer agent, Antioxidant, Anti-tumor activity, Cell line, Chalcone, Clinical data, Cytotoxic activity, Flavone, Flavonoid, Flavanol, Flavanone, Flavopiridol, Function, Isoflavone, Mechanism, Quercetin, SAR, Structure
Abstract: The potential of flavonoids to act as anti-tumor agents has been recognized but not fully understood because flavonoids are acting at several stages in cancer progression with distinct structure-function relationships. A whole family of structurally different flavonoids is herein described by reviewing some critical aspects of their pro-oxidant behavior in vitro/vivo and in cell systems by which they may work as antioxidants. Different classes of flavonoids (chalcones, flavones, isoflavones, flavanols, flavanones and anthocyanins) are synthetically mimicked using natural product structure-antioxidant activity relationships that are relevant for their enhanced function against cancer as well as severe inflammation conditions under which an increased oxidative stress is often implicated. In the context of the common mechanisms of flavonoid action, clinical data on benefits of flavonoids in fighting against cancer are discussed. A structural basis needed to improve antioxidant activity of these agents is elaborated in more detail.
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Cite this article as:
V. Babu Bandarugattu, K. Konduru Naveen, Nakanishi Waro, Hayashi Satoko, Ahmed Naseem and M. Mitrasinovic Petar, Experimental and Theoretical Advances in Functional Understanding of Flavonoids as Anti-Tumor Agents, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (2) . https://dx.doi.org/10.2174/1871520611313020017
DOI https://dx.doi.org/10.2174/1871520611313020017 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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