Abstract
Neoadjuvant chemotherapy is provided to patients with locally advanced breast cancer. Its main objective is to bring about a complete pathologic response which is correlated with long term patient survival, a clinical end point of preoperative chemotherapy. Besides, it may downsize the tumor, enabling breast conserving or limited mastectomy. Preoperative chemotherapy also provides the opportunity of assessing the chemosensitivity of the tumor in vivo so that postoperative chemotherapy is tailored according to the outcome of the neoadjuvant chemotherapy. Pathological complete response is considered when there is complete eradication of the local regional disease. Residual disease in the primary focus and/or axilla after preoperative chemotherapy is associated with poor prognosis. Standard preoperative and postoperative specimen collection, handling, processing, and examination are essential components of proper evaluation and reporting of pathologic response to neoadjuvant chemotherapy.
Keywords: Breast cancer, Neoadjuvant chemotherapy, Histopathology, Pathology response
Anti-Cancer Agents in Medicinal Chemistry
Title:Progress in Evaluation of Pathologic Response to Neoadjuvant Chemotherapy of Breast Cancer
Volume: 13 Issue: 2
Author(s): Estifanos P. Gebreamlak, Gary M.K. Tse and Yun Niu
Affiliation:
Keywords: Breast cancer, Neoadjuvant chemotherapy, Histopathology, Pathology response
Abstract: Neoadjuvant chemotherapy is provided to patients with locally advanced breast cancer. Its main objective is to bring about a complete pathologic response which is correlated with long term patient survival, a clinical end point of preoperative chemotherapy. Besides, it may downsize the tumor, enabling breast conserving or limited mastectomy. Preoperative chemotherapy also provides the opportunity of assessing the chemosensitivity of the tumor in vivo so that postoperative chemotherapy is tailored according to the outcome of the neoadjuvant chemotherapy. Pathological complete response is considered when there is complete eradication of the local regional disease. Residual disease in the primary focus and/or axilla after preoperative chemotherapy is associated with poor prognosis. Standard preoperative and postoperative specimen collection, handling, processing, and examination are essential components of proper evaluation and reporting of pathologic response to neoadjuvant chemotherapy.
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Cite this article as:
P. Gebreamlak Estifanos, M.K. Tse Gary and Niu Yun, Progress in Evaluation of Pathologic Response to Neoadjuvant Chemotherapy of Breast Cancer, Anti-Cancer Agents in Medicinal Chemistry 2013; 13 (2) . https://dx.doi.org/10.2174/1871520611313020006
DOI https://dx.doi.org/10.2174/1871520611313020006 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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