Abstract
The emergence of bacteria resistance to most of the currently available antibiotics has become a critical therapeutic problem. The bacteria causing both hospital and community-acquired infections are most often multidrug resistant. In view of the alarming level of antibiotic resistance between bacterial species and difficulties with treatment, alternative or supportive antibacterial cure has to be developed. The presented review focuses on the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents. We discuss several issues such as mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects of bacteriophages and phage-encoded proteins application.
Keywords: antibiotics, bacterial multidrug resistance, bacteriophage therapy, phage-encoded proteins application, Bacteriophages, ANTIMICROBIAL DRUG RESISTANCE, Bacterial Anti-Phage Resistance, PHAGE-ENCODED PROTEINS, EPS- Degrading Phage Enzymes, Bacterial Protein Synthesis
Current Protein & Peptide Science
Title:Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications
Volume: 13 Issue: 8
Author(s): Zuzanna Drulis-Kawa, Grazyna Majkowska-Skrobek, Barbara Maciejewska, Anne-Sophie Delattre and Rob Lavigne
Affiliation:
Keywords: antibiotics, bacterial multidrug resistance, bacteriophage therapy, phage-encoded proteins application, Bacteriophages, ANTIMICROBIAL DRUG RESISTANCE, Bacterial Anti-Phage Resistance, PHAGE-ENCODED PROTEINS, EPS- Degrading Phage Enzymes, Bacterial Protein Synthesis
Abstract: The emergence of bacteria resistance to most of the currently available antibiotics has become a critical therapeutic problem. The bacteria causing both hospital and community-acquired infections are most often multidrug resistant. In view of the alarming level of antibiotic resistance between bacterial species and difficulties with treatment, alternative or supportive antibacterial cure has to be developed. The presented review focuses on the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents. We discuss several issues such as mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects of bacteriophages and phage-encoded proteins application.
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Cite this article as:
Drulis-Kawa Zuzanna, Majkowska-Skrobek Grazyna, Maciejewska Barbara, Delattre Anne-Sophie and Lavigne Rob, Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications, Current Protein & Peptide Science 2012; 13 (8) . https://dx.doi.org/10.2174/138920312804871193
DOI https://dx.doi.org/10.2174/138920312804871193 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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