Synthesis and Study the Antimicrobial Activity of Novel 2-(1H-indol-3-yl)- N-(3, 4-diphenylthiazol-2(3H)-ylidene) Ethanamine Derivatives

Title:Synthesis and Study the Antimicrobial Activity of Novel 2-(1H-indol-3-yl)- N-(3, 4-diphenylthiazol-2(3H)-ylidene) Ethanamine Derivatives

Volume: 9 Issue: 2

Author(s): Ravindra M. Kumbhare, K. Vijay Kumar, Tulshiram L. Dadmal, Umesh B. Kosurkar and K. Appalanaidu

Affiliation:

Keywords: Ethanamine derivatives, Tryptamine, Thiourea, 2-Bromoacetophenone, Antibacterial, Antifungal

Abstract: A series of novel 2-(1H-indol-3-yl)-N-(3, 4-diphenylthiazol-2(3H)-ylidene) ethanamine derivatives (5a-o) were synthesized by cyclization of corresponding 1-(2-(1H-indol-3-yl) ethyl)-3-phenylthiourea 3 with 2-bromoacetophenone. All synthesized compounds were evaluated for in vitro antibacterial activity using Gram-positive bacteria and Gramnegative bacteria. In vitro antifungal activity also determined against the five fungal species. Structures of the synthesized compounds were established by elemental analysis and spectral data.

Cite this article as:

M. Kumbhare Ravindra, Vijay Kumar K., L. Dadmal Tulshiram, B. Kosurkar Umesh and Appalanaidu K., Synthesis and Study the Antimicrobial Activity of Novel 2-(1H-indol-3-yl)- N-(3, 4-diphenylthiazol-2(3H)-ylidene) Ethanamine Derivatives, Medicinal Chemistry 2013; 9 (2) . https://dx.doi.org/10.2174/1573406411309020011