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Combinatorial Chemistry & High Throughput Screening


ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

ZnO Nanoparticles-Catalyzed Cyclocondensation Reaction of Arylmethylidenepyruvic Acids with 6-Aminouracils

Author(s): Shahrzad Abdolmohammadi

Volume 16, Issue 1, 2013

Page: [32 - 36] Pages: 5

DOI: 10.2174/1386207311316010005

Price: $65


A new, efficient, and solvent-free cyclocondensation reaction of arylmethylidenepyruvic acids with 6- aminouracils is presented that uses a catalytic amount of ZnO nanoparticles (ZnO Nps) as a recyclable catalyst at 70 °C. This protocol has the advantages of high yields (91-98%), easy work-up, very short reaction time (2 h), and using environmentally friendly procedure.

Keywords: Cyclocondensation, heterogeneous catalyst, solvent-free, ZnO nanoparticles, recyclable catalyst, metal oxide, solvent-free.

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