Abstract
Hemodynamic disturbance in cerebral blood flow (CBF) is common in both Alzheimer’s disease (AD) and vascular dementia (VaD).The aim of this study is to investigate the different patterns of regional cerebral blood flow (rCBF) change and cerebrovascular reactivity (CVR) in these two types of dementia. Mean flow velocity (MFV) of middle cerebral artery and rCBF were measured by Transcranial Doppler ultrasound (TCD) and arterial spin-labeling (ASL) magnetic resonance, separately. CVR was evaluated by MFV or rCBF change in response to 5% CO2 inhalation. The ASL results showed that, rCBF was significantly lower in both the bilateral frontal and temporal lobes in AD group and lower in left frontal and temporal white matter in patients with VaD. CVR calculated by rCBF was impaired more severely in bilateral frontal cortices in AD. Conversely, TCD tests failed to demonstrate significant difference in MFV and CVR between the two groups. It is concluded that the different patterns detected by ASL in resting rCBF change and cerebrovascular reactivity in response to carbogen inhalation may serve as a potential marker to distinguish AD and VaD.
Keywords: Alzheimer’s disease, Arterial spin-labeling magnetic resonance, Cerebrovascular reactivity, Regional cerebral blood flow, Vascular dementia
Current Neurovascular Research
Title:Regional Cerebral Blood Flow and Cerebrovascular Reactivity in Alzheimer’s Disease and Vascular Dementia Assessed by Arterial Spinlabeling Magnetic Resonance Imaging
Volume: 10 Issue: 1
Author(s): Yong-Zhe Gao, Jun-Jian Zhang, Hui Liu, Guang-Yao Wu, Li Xiong and Min Shu
Affiliation:
Keywords: Alzheimer’s disease, Arterial spin-labeling magnetic resonance, Cerebrovascular reactivity, Regional cerebral blood flow, Vascular dementia
Abstract: Hemodynamic disturbance in cerebral blood flow (CBF) is common in both Alzheimer’s disease (AD) and vascular dementia (VaD).The aim of this study is to investigate the different patterns of regional cerebral blood flow (rCBF) change and cerebrovascular reactivity (CVR) in these two types of dementia. Mean flow velocity (MFV) of middle cerebral artery and rCBF were measured by Transcranial Doppler ultrasound (TCD) and arterial spin-labeling (ASL) magnetic resonance, separately. CVR was evaluated by MFV or rCBF change in response to 5% CO2 inhalation. The ASL results showed that, rCBF was significantly lower in both the bilateral frontal and temporal lobes in AD group and lower in left frontal and temporal white matter in patients with VaD. CVR calculated by rCBF was impaired more severely in bilateral frontal cortices in AD. Conversely, TCD tests failed to demonstrate significant difference in MFV and CVR between the two groups. It is concluded that the different patterns detected by ASL in resting rCBF change and cerebrovascular reactivity in response to carbogen inhalation may serve as a potential marker to distinguish AD and VaD.
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Gao Yong-Zhe, Zhang Jun-Jian, Liu Hui, Wu Guang-Yao, Xiong Li and Shu Min, Regional Cerebral Blood Flow and Cerebrovascular Reactivity in Alzheimer’s Disease and Vascular Dementia Assessed by Arterial Spinlabeling Magnetic Resonance Imaging, Current Neurovascular Research 2013; 10 (1) . https://dx.doi.org/10.2174/1567202611310010007
DOI https://dx.doi.org/10.2174/1567202611310010007 |
Print ISSN 1567-2026 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5739 |
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