Abstract
LT, LIGHT, and TNF are core family members of the TNFR superfamily of cytokines. LT and LIGHT, produced primarily by lymphocytes, interact with LTβR expressed by stromal and epithelial cells. Extensive studies over the last decade have revealed a critical role of LT-LTβR interactions for organogenesis and maintenance of the secondary lymphoid organs and in the generation of an efficient humoral immune response to various pathogens. LTβRs function beyond the lymphoid organs shows valuable potential yet remains largely undefined. Recent studies indicate that LTβR signaling is required for liver regeneration, hepatitis, and hepatic lipid metabolism. The balance of beneficial and detrimental effects of LTβR is critical for understanding the mechanisms of autoimmune disease and liver function and may open a new avenue for therapeutic intervention. This review will discuss recent advances in understanding LTβRs role in various human and murine disease models while focusing on its regulation of and implications in various liver related diseases.
Keywords: Lymphotoxin, lymphotoxin beta receptor, tumor necrosis factor, LIGHT, atherosclerosis, lipid metabolism, hepatic lipase
Current Molecular Medicine
Title: The Role of Lymphotoxin Receptor Signaling in Diseases
Volume: 7 Issue: 6
Author(s): Alexei V. Tumanov, Peter A. Christiansen and Yang-Xin Fu
Affiliation:
Keywords: Lymphotoxin, lymphotoxin beta receptor, tumor necrosis factor, LIGHT, atherosclerosis, lipid metabolism, hepatic lipase
Abstract: LT, LIGHT, and TNF are core family members of the TNFR superfamily of cytokines. LT and LIGHT, produced primarily by lymphocytes, interact with LTβR expressed by stromal and epithelial cells. Extensive studies over the last decade have revealed a critical role of LT-LTβR interactions for organogenesis and maintenance of the secondary lymphoid organs and in the generation of an efficient humoral immune response to various pathogens. LTβRs function beyond the lymphoid organs shows valuable potential yet remains largely undefined. Recent studies indicate that LTβR signaling is required for liver regeneration, hepatitis, and hepatic lipid metabolism. The balance of beneficial and detrimental effects of LTβR is critical for understanding the mechanisms of autoimmune disease and liver function and may open a new avenue for therapeutic intervention. This review will discuss recent advances in understanding LTβRs role in various human and murine disease models while focusing on its regulation of and implications in various liver related diseases.
Export Options
About this article
Cite this article as:
Tumanov V. Alexei, Christiansen A. Peter and Fu Yang-Xin, The Role of Lymphotoxin Receptor Signaling in Diseases, Current Molecular Medicine 2007; 7 (6) . https://dx.doi.org/10.2174/156652407781695701
DOI https://dx.doi.org/10.2174/156652407781695701 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Thalidomide as an Immunotherapeutic Agent: The Effects on Neutrophil- Mediated Inflammation
Current Pharmaceutical Design The Role of Anaphylatoxins C3a and C5a in Regulating Innate and Adaptive Immune Responses
Inflammation & Allergy - Drug Targets (Discontinued) Immune-Regulatory Mechanisms of Classical and Experimental Multiple Sclerosis Drugs: A Special Focus on Helminth-Derived Treatments
Current Medicinal Chemistry α-Galactosylceramide: Potential Immunomodulatory Activity and Future Application [General Articles]
Current Medicinal Chemistry Phosphoinositide 3-Kinase Gamma (PI3Kγ) Inhibitors for the Treatment of Inflammation and Autoimmune Disease
Recent Patents on Inflammation & Allergy Drug Discovery Human Fetal Mesenchymal Stem Cells
Current Stem Cell Research & Therapy Therapeutic Targeting of CD6 in Autoimmune Diseases: A Review of Cuban Clinical Studies with the Antibodies IOR-T1 and Itolizumab
Current Drug Targets Targeting Toll-like Receptors in Autoimmunity
Current Drug Targets The Yin and Yang of Non-Neuronal α7-Nicotinic Receptors in Inflammation and Autoimmunity
Current Drug Targets Lysophospholipid Receptors as Potential Drug Targets in Tissue Transplantation and Autoimmune Diseases
Current Pharmaceutical Design Targeting Cytosolic Phospholipase A2α for Novel Anti-Inflammatory Agents
Current Medicinal Chemistry Nanocarriers as Tools in Delivering Active Compounds for Immune System Related Pathologies
Recent Patents on Nanotechnology Assessment of Endothelial Function by Positron Emission Tomography
Current Cardiology Reviews Unique Phenotypes and Functions of Follicular Helper T Cells and Regulatory T Cells in Sjögren’s Syndrome
Current Rheumatology Reviews Autoimmune Diseases and Infections: A Controversial Relationship
Current Immunology Reviews (Discontinued) Treatment of Central Nervous System Involvement Associated with Primary Sjogrens Syndrome
Current Pharmaceutical Design One Special Question to Start with: Can HIF/NFkB be a Target in Inflammation?
Endocrine, Metabolic & Immune Disorders - Drug Targets Roles of Glycans and Glycopeptides in Immune System and Immune-Related Diseases
Current Medicinal Chemistry Altered Peptide Ligand Antagonism: From Immune Evasion to Immunotherapy
Drug Design Reviews - Online (Discontinued) Multivalent Compounds for Antigen-Specific B Cell Tolerance and Treatment of Autoimmune Diseases
Current Medicinal Chemistry