Abstract
Benzimidazole (benzimidazolone) template certainly deserves the title of “privileged scaffold” in antiviral drug research field because of the versatility and potential to yield derivatives with a wide range of antiviral activity, such as anti-HIV, anti-HCV, anti-HBV, anti-HCMV, anti-RSV and anti-rhino/enteroviruses activities, etc. These different biological properties of benzimidazole (benzimidazolone) derivatives have motivated new studies in searching for novel derivatives with improved activity and also other applications in pharmaceutical field. No systematic review is available in the literature on the benzimidazole (benzimidazolone) derivatives concerning the design of potent antiviral inhibitors. Owing to the importance of this heterocyclic system, the aim of this review is to present the main aspects of exploring antiviral properties, such as the structural modifications, the structure-activity relationship (SAR), making an effort to highlight the importance and therapeutic potentials of the benzimidazole (one) scaffold in the present antiviral agents.
Keywords: Heterocycle, benzimidazole, benzimidazolone, antiviral activity, drug design.
Mini-Reviews in Organic Chemistry
Title:Benzimidazole Heterocycle as a Privileged Scaffold in Antiviral Agents
Volume: 9 Issue: 4
Author(s): Peng Zhan, Dongyue Li, Junyi Li, Xuwang Chen and Xinyong Liu
Affiliation:
Keywords: Heterocycle, benzimidazole, benzimidazolone, antiviral activity, drug design.
Abstract: Benzimidazole (benzimidazolone) template certainly deserves the title of “privileged scaffold” in antiviral drug research field because of the versatility and potential to yield derivatives with a wide range of antiviral activity, such as anti-HIV, anti-HCV, anti-HBV, anti-HCMV, anti-RSV and anti-rhino/enteroviruses activities, etc. These different biological properties of benzimidazole (benzimidazolone) derivatives have motivated new studies in searching for novel derivatives with improved activity and also other applications in pharmaceutical field. No systematic review is available in the literature on the benzimidazole (benzimidazolone) derivatives concerning the design of potent antiviral inhibitors. Owing to the importance of this heterocyclic system, the aim of this review is to present the main aspects of exploring antiviral properties, such as the structural modifications, the structure-activity relationship (SAR), making an effort to highlight the importance and therapeutic potentials of the benzimidazole (one) scaffold in the present antiviral agents.
Export Options
About this article
Cite this article as:
Zhan Peng, Li Dongyue, Li Junyi, Chen Xuwang and Liu Xinyong, Benzimidazole Heterocycle as a Privileged Scaffold in Antiviral Agents, Mini-Reviews in Organic Chemistry 2012; 9 (4) . https://dx.doi.org/10.2174/157019312804699456
DOI https://dx.doi.org/10.2174/157019312804699456 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Synthesis and Anticancer Activity of Some 1H-inden-1-one Substituted (Heteroaryl)Acetamide Derivatives
Letters in Drug Design & Discovery Chromatin Structure and Epigenetics of Tumour Cells: A Review
Cardiovascular & Hematological Disorders-Drug Targets Editorial Review of 2012
Current Radiopharmaceuticals Tyrosine Kinase Inhibitors
Current Cancer Drug Targets Epigenetics and Adult Acute Myeloid Leukemia
Current Pharmacogenomics and Personalized Medicine Toxicity and Surface Modification of Dendrimers: A Critical Review
Current Drug Delivery Retinoid Receptors in Inflammatory Responses: A Potential Target for Pharmacology
Current Drug Targets - Inflammation & Allergy Immunotherapeutic Options for Pediatric Malignancies
Current Immunology Reviews (Discontinued) HDAC Inhibitors as Novel Anti-Cancer Therapeutics
Recent Patents on Anti-Cancer Drug Discovery Polo-Like Kinases Inhibitors
Current Medicinal Chemistry Pharmacological and Clinical Studies on Purine Nucleoside Analogs- New Anticancer Agents
Mini-Reviews in Medicinal Chemistry “Non-Taxifolin” Derived Flavonolignans: Phytochemistry and Biology
Current Pharmaceutical Design Pathways Related to the Anti-Cancer Effects of Metabolites Derived from Cerrado Biome Native Plants: An Update and Bioinformatics Analysis on Oral Squamous Cell Carcinoma
Protein & Peptide Letters Targeting Glioblastoma Stem Cells: Cell Surface Markers
Current Medicinal Chemistry The Ubiquitin+Proteasome Protein Degradation Pathway as a Therapeutic Strategy in the Treatment of Solid Tumor Malignancies
Anti-Cancer Agents in Medicinal Chemistry Drug-Membrane Interactions: Significance for Medicinal Chemistry
Current Medicinal Chemistry Development of Patents and Clinical Trials on Regenerative Therapy: Gene Therapy
Recent Patents on Regenerative Medicine Allosteric Targeting of Aurora A Kinase Using Small Molecules: A Step Forward Towards Next Generation Medicines?
Current Medicinal Chemistry Applications of Umbilical Cord Derived Mesenchymal Stem Cells in Autoimmune and Immunological Disorders: From Literature to Clinical Practice
Current Stem Cell Research & Therapy New Developments in Targeted Analysis of Protein Posttranslational Modifications
Current Proteomics