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Current Metabolomics

Editor-in-Chief

ISSN (Print): 2213-235X
ISSN (Online): 2213-2368

Magnetic Resonance-Based Metabolomics for Understanding Neurological Disorders: Current Status and Statistical Considerations

Author(s): Anthony D. Maher, Victor Solo and Caroline D. Rae

Volume 1 , Issue 1 , 2013

Page: [2 - 14] Pages: 13

DOI: 10.2174/2213235X11301010002

Abstract

Investigation of the metabolic status of the brain is problematic due to its inaccessibility. NMR-based metabolomics offers potential diagnostic capabilities via measurement of brain or related biofluid metabolic profiles. In this review we examine the extent to which NMR and MRS have been employed in studies of neurological disorders, the information obtainable, the strengths and limitations of each technology. The potential for wider application of these complementary technologies in metabolomics research is discussed, both in isolation and in combination. The current status of the statistical framework for dealing with these data sets is also examined and suggestions offered for future directions.

Keywords: Blood plasma, cerebrospinal fluid, magnetic resonance spectroscopy.


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