Biology of Circulating Nucleic Acids and Possible Roles in Diagnosis and Treatment in Diabetes and Cancer

Peter      B. Gahan

Abstract

The presence of DNA and RNA circulating in human plasma and serum is described. The possible sources of the DNA/RNA in blood, their ability to enter other cells and to express in the recipient cells are discussed and the relationship with metastases considered. The possible role(s) of the DNA/RNA in clinical diagnosis, in monitoring treatment and in prognosis are considered for diabetes and oncology.

Keywords: Circulating DNA/RNA, plasma/serum, diabetes, cancer, diagnosis, nucleic acid uptake/expression, recipient cells, human plasma, human blood, severe sepsis, clinical patients, systemic lupus erythematosus patients, cancer patients, tumour cell derived, cardiovascular disease