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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Hydroarylation of Substituted Norbornene Amino Acids: Studies on Long-Range Stereo-Electronic Effects on the Regioselectivity of the Addition

Author(s): Alessandro Ruffoni, Alessandro Casoni, Maria Luisa Gelmi, Sara Pellegrino and Francesca Clerici

Volume 16, Issue 22, 2012

Page: [2724 - 2738] Pages: 15

DOI: 10.2174/138527212804004472

Price: $65


Studies on the Pd-catalyzed hydroarylation reaction of a library of differently substituted norbornene amino acid derivatives with numerous halogenoarenes are described. The effect on the regiochemistry of remote substituents, arylating agents and reaction conditions was considered. The reaction occurred with moderate to good yields and a moderate level of regioselectivity being the coupling at C-5 favorite.

Keywords: Bicyclic alkenes, catalysis, hydroarylations, norbornene amino acid derivatives, Pd-catalyzed reactions, regioselectivity

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