Abstract
Bunyaviridae family consists of vector borne lethal viruses, stands out as the largest virus family with its 350 members. One such virus of this family, Crimean- Congo hemorrhagic fever virus (CCHFV) is transmitted through bites of ixodid ticks or by direct contact with blood from infected animals. Crimean-Congo haemorrhagic fever (CCHF) is a severe disease in humans which is endemic in large parts of the world with a high mortality rate. This virus could also be used as a bioterrorism agent due to its human-to-human transmission with no specific therapy. The pathogenicity factor of CCHFV is unexplored due to the lack of animal models. CCHFV, being an RNA virus, is able to mutate rapidly hence preventing the development of effective therapy against it. Till now ribavarin is the only available drug for supportive treatment but has many side-effects. New technologies like RNA interference have emerged as a solution for epidemics of CCHF. RNAi is a sequence specific approach, has been used successfully against different pathogens. This review focuses on designing and application of RNAi with emphasis on the role of bioinformatics for the anti CCHFV therapeutic development strategy.
Keywords: Crimean-Congo hemorrhagic fever, CCHFV, bunyaviridae, nairoviridae, RNAi, siRNA, epidemiology, glycoproteins, antiviral therapy, nucleoprotein
Current Bioinformatics
Title:Crimean-Congo Hemorrhagic Fever Virus: Strategies to Combat with an Emerging Threat to Human
Volume: 7 Issue: 4
Author(s): Shivendra Pratap, Manju Narwal, Aditya Dev, Sonali Dhindwal, Shailly Tomar and Pravindra Kumar
Affiliation:
Keywords: Crimean-Congo hemorrhagic fever, CCHFV, bunyaviridae, nairoviridae, RNAi, siRNA, epidemiology, glycoproteins, antiviral therapy, nucleoprotein
Abstract: Bunyaviridae family consists of vector borne lethal viruses, stands out as the largest virus family with its 350 members. One such virus of this family, Crimean- Congo hemorrhagic fever virus (CCHFV) is transmitted through bites of ixodid ticks or by direct contact with blood from infected animals. Crimean-Congo haemorrhagic fever (CCHF) is a severe disease in humans which is endemic in large parts of the world with a high mortality rate. This virus could also be used as a bioterrorism agent due to its human-to-human transmission with no specific therapy. The pathogenicity factor of CCHFV is unexplored due to the lack of animal models. CCHFV, being an RNA virus, is able to mutate rapidly hence preventing the development of effective therapy against it. Till now ribavarin is the only available drug for supportive treatment but has many side-effects. New technologies like RNA interference have emerged as a solution for epidemics of CCHF. RNAi is a sequence specific approach, has been used successfully against different pathogens. This review focuses on designing and application of RNAi with emphasis on the role of bioinformatics for the anti CCHFV therapeutic development strategy.
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Cite this article as:
Pratap Shivendra, Narwal Manju, Dev Aditya, Dhindwal Sonali, Tomar Shailly and Kumar Pravindra, Crimean-Congo Hemorrhagic Fever Virus: Strategies to Combat with an Emerging Threat to Human, Current Bioinformatics 2012; 7 (4) . https://dx.doi.org/10.2174/157489312803900901
DOI https://dx.doi.org/10.2174/157489312803900901 |
Print ISSN 1574-8936 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-392X |
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