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Recent Patents on Biotechnology

Editor-in-Chief

ISSN (Print): 1872-2083
ISSN (Online): 2212-4012

Ryanodine Receptor Patents

Author(s): Alexander Kushnir and Andrew R. Marks

Volume 6 , Issue 3 , 2012

Page: [157 - 166] Pages: 10

DOI: 10.2174/1872208311206030157

Price: $65

Abstract

Research over the past two decades has implicated dysfunction of the ryanodine receptor (RyR), a Ca2+ release channel on the sarcoplasmic reticulum (SR) required for excitation-contraction (EC) coupling, in the pathogenesis of cardiac and skeletal myopathies. These discoveries have led to the development of novel drugs, screening tools, and research methods. The patents associated with these advances tell the story of the initial discovery of RyRs as a target for plant alkaloids, to their central role in cardiac and skeletal muscle excitation-contraction coupling, and ongoing clinical trials with a novel class of drugs called RycalsTM that inhibit pathological intracellular Ca2+ leak. Additionally, these patents highlight questions, controversies, and future directions of the RyR field.

Keywords: Ryanodine, calcium, EC-coupling, myocardium, skeletal muscle, sarcoplasmic reticulum (SR), calcium leakage, leaky SR, Rycal, JTV519, S107, heart failure, malignant hyperthermia, arrhythmias, patents


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