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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Adiponectin, an Anti-Carcinogenic Hormone? a Systematic Review on Breast, Colorectal, Liver and Prostate Cancer

Author(s): S. Perrier and T. Jarde

Volume 19 , Issue 32 , 2012

Page: [5501 - 5512] Pages: 12

DOI: 10.2174/092986712803833137

Price: $65


Adiponectin is an adipose tissue-derived hormone, expressed almost exclusively in adipose tissue, with significant antidiabetic, anti-atherosclerotic, anti-inflammatory and anti-proliferative properties. The anti-carcinogenic effects of adiponectin result from two main mechanisms: a modulation in the signaling pathways involved in proliferation process and a subtle regulation of the apoptotic response. In this review, we present recent findings on the association of adiponectin with the risk of several malignancies (breast, colorectal, liver and prostate cancers), as well as data on underlying molecular mechanisms by which adiponectin plays a substantial role in cancer pathogenesis.

Keywords: Adiponectin, adipoR1, adipoR2, adiponectin signaling, issue-derived hormone, adipose tissue, "adiponectin", "ignaling pathways", "proliferation process", "cancer pathogenesis"

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