Abstract
A large body of research including animal and human studies has confirmed the crucial role of the serotonin (5-HT) system in the regulation of anxiety-related behaviour and traits. In the past decade, the functional status of the 5-HT system in anxiety disorders has been regularly investigated by novel neuroimaging techniques, such as single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Although these studies shed more light on several aspects of the 5-HT functioning in patients with anxiety disorders, the current knowledge about the specific role of the 5-HT system in particular anxiety phenotypes remains fragmentary. In this paper, we review the available data from SPECT and PET imaging studies of the 5-HT system in anxiety disorders, attempt to dissect the involvement of the 5-HT in neural circuits of anxiety and discuss some issues that need to be considered for further research in this area.
Keywords: Anxiety disorder, serotonin, PET, SPECT, neuroimaging
Current Pharmaceutical Design
Title:Neuroimaging of Serotonin System in Anxiety Disorders
Volume: 18 Issue: 35
Author(s): Eduard Maron, David Nutt and Jakov Shlik
Affiliation:
Keywords: Anxiety disorder, serotonin, PET, SPECT, neuroimaging
Abstract: A large body of research including animal and human studies has confirmed the crucial role of the serotonin (5-HT) system in the regulation of anxiety-related behaviour and traits. In the past decade, the functional status of the 5-HT system in anxiety disorders has been regularly investigated by novel neuroimaging techniques, such as single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Although these studies shed more light on several aspects of the 5-HT functioning in patients with anxiety disorders, the current knowledge about the specific role of the 5-HT system in particular anxiety phenotypes remains fragmentary. In this paper, we review the available data from SPECT and PET imaging studies of the 5-HT system in anxiety disorders, attempt to dissect the involvement of the 5-HT in neural circuits of anxiety and discuss some issues that need to be considered for further research in this area.
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Cite this article as:
Maron Eduard, Nutt David and Shlik Jakov, Neuroimaging of Serotonin System in Anxiety Disorders, Current Pharmaceutical Design 2012; 18 (35) . https://dx.doi.org/10.2174/138161212803530844
DOI https://dx.doi.org/10.2174/138161212803530844 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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