Abstract
In the present review we integrated findings from microarray analyses of anticonvulsant treatment, discussing the replicability of the findings and their corroboration with data obtained from patients and with information from other fields of study. We further relate to the duality of several antiepileptic drugs exhibiting both anticonvulsant and moodstabilizing effects in the treatment of epilepsy and bipolar disorder, respectively.
Keywords: Epilepsy, anticonvulsants, microarrays, mood-stabilizers, Epileptic Tissue, Cytoprotection, gene expression, multiple sclerosis, inhibitory synapses, mood-stabilizing drugs, glutamate-induced apoptotic cell death, Antidepressants, ectopic granule cells, mood disorders, GABAergic dysfunction
Current Psychopharmacology
Title:Microarray Studies in Understanding the Mechanism of Action of Antiepileptic Drugs
Volume: 1
Author(s): Lilach Toker, RH Belmaker and Galila Agam
Affiliation:
Keywords: Epilepsy, anticonvulsants, microarrays, mood-stabilizers, Epileptic Tissue, Cytoprotection, gene expression, multiple sclerosis, inhibitory synapses, mood-stabilizing drugs, glutamate-induced apoptotic cell death, Antidepressants, ectopic granule cells, mood disorders, GABAergic dysfunction
Abstract: In the present review we integrated findings from microarray analyses of anticonvulsant treatment, discussing the replicability of the findings and their corroboration with data obtained from patients and with information from other fields of study. We further relate to the duality of several antiepileptic drugs exhibiting both anticonvulsant and moodstabilizing effects in the treatment of epilepsy and bipolar disorder, respectively.
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Cite this article as:
Toker Lilach, Belmaker RH and Agam Galila, Microarray Studies in Understanding the Mechanism of Action of Antiepileptic Drugs, Current Psychopharmacology 2012; 1 (4) . https://dx.doi.org/10.2174/2211556011201040327
DOI https://dx.doi.org/10.2174/2211556011201040327 |
Print ISSN 2211-5560 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5579 |
Call for Papers in Thematic Issues
Breakthroughs in drug design, development and delivery system for the management of neuro-psychiatric disorders
Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. This proposal describes the ...read more
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