Technological Barriers in the Use of Electrochemical Microsensors and Microbiosensors for in vivo Analysis of Neurological Relevant Substances

Title:Technological Barriers in the Use of Electrochemical Microsensors and Microbiosensors for in vivo Analysis of Neurological Relevant Substances

Volume: 10 Issue: 3

Author(s): Bogdan Bucur

Affiliation:

• National Institute of Research and Development for Biological Sciences, Bioanalysis Center, 296 Splaiul Independentei, 060031, Bucharest, Romania.,Oman

Keywords: Brain in vivo analysis, microelectrodes, microbiosensors, neurotransmitters, neuromodulators

Abstract: In this paper is presented an overview of the technological barriers faced by the in vivo brain analysis with microelectrodes. Numerous microsensors and enzymatic microbiosensors have been developed for the real time monitoring of neurotransmitters, neuromodulators, drugs and diverse other biological relevant substances. A clear understanding of the working principle, advantages and limitations is essential for the acquisition of valid data in neurological investigations. Some of the aspects presented here refer to: microelectrode insertion and positioning related to possibilities to minimize tissue damage, spatial and temporal resolution of the measurements, actual controversies in data interpretation and sensor calibration, simultaneous detection of multiple analytes, interferences and state of the art in the development of wireless devices.

Cite this article as:

Bucur Bogdan, Technological Barriers in the Use of Electrochemical Microsensors and Microbiosensors for in vivo Analysis of Neurological Relevant Substances, Current Neuropharmacology 2012; 10(3) . https://dx.doi.org/10.2174/157015912803217350