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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy: In-Water Synthesis of "Difficult Sequences"

Author(s): Keiko Hojo, Hideki Ichikawa, Asaki Hara, Mare Onishi, Koichi Kawasaki and Yoshinobu Fukumori

Volume 19, Issue 11, 2012

Page: [1231 - 1236] Pages: 6

DOI: 10.2174/092986612803217114

Price: $65

Abstract

A microwave assisted peptide synthesis in water using nanosized Fmoc-amino acids was developed. 5, 7, and 10 mer peptides (Leu-enkephalinamide, dermorphinamide, and a typical difficult sequence, ACP (65-74) peptide) were successfully synthesized in water according to Fmoc chemistry using water-dispersible nanoparticles with microwave irradiation.

Keywords: Solid-phase synthesis, Fmoc-amino acid, synthesis in water, difficult sequence, nanoparticles, microwave-assisted synthesis

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