Abstract
The most commonly encountered carcinoma of the sinonasal tract is the keratinizing/ non-keratinizing squamous cell carcinoma. However, this complex anatomic location may represent the site of other epithelial malignant neoplasms of varying histogenesis. These tumors are clinically aggressive and often fatal; historically, treatment outcomes have been poor. Differentiating these tumor types may have clinical impact as advances in therapeutic intervention could increase survival, quality of life and occasionally result in a cure. This review focuses on recent advances in the molecular and phenotypic characterization of sinonasal carcinomas and their impact on diagnosis and treatment.
Keywords: Sinonasal carcinoma, Phenotype, Genome analysis, Targeted therapy
Current Cancer Therapy Reviews
Title:Sinonasal Carcinoma: Updated Phenotypic and Molecular Characterization
Volume: 8 Issue: 3
Author(s): Diana Bell and Ehab Y. Hanna
Affiliation:
Keywords: Sinonasal carcinoma, Phenotype, Genome analysis, Targeted therapy
Abstract: The most commonly encountered carcinoma of the sinonasal tract is the keratinizing/ non-keratinizing squamous cell carcinoma. However, this complex anatomic location may represent the site of other epithelial malignant neoplasms of varying histogenesis. These tumors are clinically aggressive and often fatal; historically, treatment outcomes have been poor. Differentiating these tumor types may have clinical impact as advances in therapeutic intervention could increase survival, quality of life and occasionally result in a cure. This review focuses on recent advances in the molecular and phenotypic characterization of sinonasal carcinomas and their impact on diagnosis and treatment.
Export Options
About this article
Cite this article as:
Bell Diana and Y. Hanna Ehab, Sinonasal Carcinoma: Updated Phenotypic and Molecular Characterization, Current Cancer Therapy Reviews 2012; 8 (3) . https://dx.doi.org/10.2174/157339412802653137
DOI https://dx.doi.org/10.2174/157339412802653137 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
Call for Papers in Thematic Issues
Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Application of MALDI/SELDI Mass Spectrometry to Cancer Biomarker Discovery and Validation
Current Proteomics New Prognostic Markers and Potential Therapeutic Targets in Human Testicular Germ Cell Tumors
Current Medicinal Chemistry Connexins as Precocious Markers and Molecular Targets for Chemical and Pharmacological Agents in Carcinogenesis
Current Medicinal Chemistry The Renin-angiotensin System as a Target of Novel Anticancer Therapy
Current Pharmaceutical Design The Carnitine Transporter Network: Interactions with Drugs
Current Chemical Biology Phytochemical-Mediated Glioma Targeted Treatment: Drug Resistance and Novel Delivery Systems
Current Medicinal Chemistry Progesterone Receptor Agonists and Antagonists as Anticancer Agents
Mini-Reviews in Medicinal Chemistry Promising Protective Effects of Chrysin in Cardiometabolic Diseases
Current Drug Targets HLA-G Expression in Cancers: Potential Role in Diagnosis, Prognosis and Therapy
Endocrine, Metabolic & Immune Disorders - Drug Targets Notch-Associated MicroRNAs in Cancer
Current Drug Targets Recent Patents on Alphavirus Protein Expression and Vector Production
Recent Patents on Biotechnology Higher Placental Anti-Inflammatory IL-10 Cytokine Expression in HIV-1 Infected Women Receiving Longer Zidovudine Prophylaxis Associated with Nevirapine
Current HIV Research Fungal Proteins with Antiproliferative and Anticancer Activities
Protein & Peptide Letters Standardization of Epitopes for Human Chorionic Gonadotropin (hCG) Immunoassays
Current Medicinal Chemistry Gonadotropin-Releasing Hormone (GnRH) Receptors in Tumors: a New Rationale for the Therapeutical Application of GnRH Analogs in Cancer Patients?
Current Cancer Drug Targets Negative Glucocorticoid Receptor Response Elements and their Role in Glucocorticoid Action
Current Pharmaceutical Design Cellular Relationships of Testicular Germ Cell Tumors Determined by Partial Canonical Correlation Analysis of Gene Expression Signatures
Current Bioinformatics Mitochondrial Toxicity in HAART: An Overview of In Vitro Evidence
Current Pharmaceutical Design CEBP Epigenetic Dysregulation as a Drug Target for the Treatment of Hematologic and Gynecologic Malignancies
Current Drug Targets Nuclear Hormone Receptors and Female Reproduction
Current Molecular Medicine