Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Immunological Aspects of the Complex Regional Pain Syndrome (CRPS)

Author(s): Heidrun H. Kramer

Volume 18, Issue 29, 2012

Page: [4546 - 4549] Pages: 4

DOI: 10.2174/138161212802502206

Price: $65

Abstract

Limb trauma can lead to the development of a complex regional pain syndrome (CRPS). CRPS is a descriptive term of a variety of different symptoms. According to the current IASP-approved criteria, human CRPS can be diagnosed if a combination of signs is present: continuing pain and hyperalgesia, disproportionate to the initial trauma, skin temperature and colour asymmetry, sweating asymmetry, edema, decreased range of motion, and trophic changes. The diagnosis and treatment of human CRPS can be demanding and the pathophysiology underlying the disease is still under investigation. Immunological aspects are considered to play an important role in the development of CRPS. The impact of elevated pro-inflammatory cytokines systemically as well as locally, increased neurogenic inflammation and auto-antibodies in the pathophysiological development of CRPS are discussed in this review.

Keywords: CRPS, cytokines, neuropeptides, autoimmunity, Limb trauma, pain, hyperalgesia, trauma, sweating, edema.


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy