Molecular Hybridization: A Useful Tool in the Design of New Drug Prototypes

Title: Molecular Hybridization: A Useful Tool in the Design of New Drug Prototypes

Volume: 14 Issue: 17

Author(s): Claudio Viegas-Junior, Amanda Danuello, Vanderlan da Silva Bolzani, Eliezer J. Barreiro and Carlos Alberto Manssour Fraga

Affiliation:

Keywords: Molecular hybridization, Drug design, Hybrid compounds, Pharmacophoric group combination

Abstract: Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hybrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can result in compounds presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects. So, in this paper, we described several examples of different strategies for drug design, discovery and pharmacomodulation focused on new innovative hybrid compounds presenting analgesic, anti-inflammatory, platelet anti-aggregating, anti-infectious, anticancer, cardio- and neuroactive properties.

Cite this article as:

Claudio Viegas-Junior , Amanda Danuello , Vanderlan da Silva Bolzani , Eliezer J. Barreiro and Carlos Alberto Manssour Fraga , Molecular Hybridization: A Useful Tool in the Design of New Drug Prototypes, Current Medicinal Chemistry 2007; 14(17) . https://dx.doi.org/10.2174/092986707781058805