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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Molecular Hybridization: A Useful Tool in the Design of New Drug Prototypes

Author(s): Claudio Viegas-Junior, Amanda Danuello, Vanderlan da Silva Bolzani, Eliezer J. Barreiro and Carlos Alberto Manssour Fraga

Volume 14, Issue 17, 2007

Page: [1829 - 1852] Pages: 24

DOI: 10.2174/092986707781058805

Price: $65


Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hybrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can result in compounds presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects. So, in this paper, we described several examples of different strategies for drug design, discovery and pharmacomodulation focused on new innovative hybrid compounds presenting analgesic, anti-inflammatory, platelet anti-aggregating, anti-infectious, anticancer, cardio- and neuroactive properties.

Keywords: Molecular hybridization, Drug design, Hybrid compounds, Pharmacophoric group combination

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