Abstract
Cancer treatments often lose their effectiveness due to the development of multiple drug resistance. Thus, identification of key proteins involved in the tumorigenic process and the survival mechanism(s), coupled with the design of novel therapeutic compounds (such as small molecule inhibitors), are essential steps towards the establishment of improved anticancer treatment strategies. DNA repair pathways and their proteins have been exposed as potential targets for combinatorial anticancer therapies that involve DNA-interactive cytotoxins, such as alkylating agents, because of their central role in providing resistance against DNA damage. In addition, an understanding of the tumor-specific genetics and associated DNA repair capacity has allowed research scientists and clinicians to begin to devise more targeted treatment strategies based on the concept of synthetic lethality. In this review, the repair mechanisms, as well as the links to cancer progression and treatment, of three key proteins that function in the base excision repair pathway, i.e. APE1, POLβ, and FEN1, are discussed.
Keywords: AP or abasic endonuclease, DNA polymerase, flap endonuclease, carcinogenesis, repair inhibitor, Cancer treatments, drug resistance, key proteins, tumorigenic process, survival mechanism(s)
Current Medicinal Chemistry
Title:Base Excision Repair: Contribution to Tumorigenesis and Target in Anticancer Treatment Paradigms
Volume: 19 Issue: 23
Author(s): J. L. Illuzzi and D. M. Wilson III
Affiliation:
Keywords: AP or abasic endonuclease, DNA polymerase, flap endonuclease, carcinogenesis, repair inhibitor, Cancer treatments, drug resistance, key proteins, tumorigenic process, survival mechanism(s)
Abstract: Cancer treatments often lose their effectiveness due to the development of multiple drug resistance. Thus, identification of key proteins involved in the tumorigenic process and the survival mechanism(s), coupled with the design of novel therapeutic compounds (such as small molecule inhibitors), are essential steps towards the establishment of improved anticancer treatment strategies. DNA repair pathways and their proteins have been exposed as potential targets for combinatorial anticancer therapies that involve DNA-interactive cytotoxins, such as alkylating agents, because of their central role in providing resistance against DNA damage. In addition, an understanding of the tumor-specific genetics and associated DNA repair capacity has allowed research scientists and clinicians to begin to devise more targeted treatment strategies based on the concept of synthetic lethality. In this review, the repair mechanisms, as well as the links to cancer progression and treatment, of three key proteins that function in the base excision repair pathway, i.e. APE1, POLβ, and FEN1, are discussed.
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Cite this article as:
L. Illuzzi J. and M. Wilson III D., Base Excision Repair: Contribution to Tumorigenesis and Target in Anticancer Treatment Paradigms, Current Medicinal Chemistry 2012; 19 (23) . https://dx.doi.org/10.2174/092986712802002581
DOI https://dx.doi.org/10.2174/092986712802002581 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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