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Current Vascular Pharmacology


ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Platelet Function and Signaling in Diabetes Mellitus

Author(s): Voahanginirina Randriamboavonjy and Ingrid Fleming

Volume 10, Issue 5, 2012

Page: [532 - 538] Pages: 7

DOI: 10.2174/157016112801784639

Price: $65


Diabetes mellitus is associated with the accelerated development of vascular disease and there is evidence that platelets actively contribute to this process. Certainly, platelets are able to modulate the function of endothelial and vascular smooth muscle cells via the direct release of growth factors and pro-inflammatory chemokines but also via the production of microparticles which function as a transcellular delivery system for micro RNAs. This article reviews the intracellular signaling mechanisms underlying the increased activation of diabetic platelets and the involvement of platelets in atherothrombosis development.

Keywords: Atherothrombosis, calpain, chemokines, diabetes, platelets redox stress, nitric oxide, homeostasis, glycoprotein Ib/V/IX, serotonin, thrombopoiesis

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