Abstract
Chitosan based novel occlusive bioadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan, suitable surfactants (Cetyl trimethylammonium bromide and Polyquaternium-1 (Polyquad®)) and Propolis ethanolic extract were developed and evaluated in this investigation. The positive synergy was observed combined the antifungal and antioxidant capacity of synthetic and natural biomaterials into functional biocompatible gel. The in vitro antioxidant capacity (free radical scavenging by ORAC and intrinsic reducing capacity by Folin-Ciocalteu Method) was quantified and the influence of antioxidant capacity of Propolis extract on the rate of release of nystatin, from chitosan based material was investigated. These copolymer systems are able to release the drug over several weeks and therefore may be useful as a drug carrier in the treatment of oral mucosatis.
Keywords: Antiooxidants, chitosan, hydrogels, oral mucosatis, free radicals, functional materials
Current Nanoscience
Title:Alternative Chitosan Based Drug Delivery System to Fight Oral Mucositis: Synergy of Conventional and Bioactives Towards the Optimal Solution
Volume: 8 Issue: 4
Author(s): V. Tamara Perchyonok, Shengmiao Zhang and Theunis Oberholzer
Affiliation:
Keywords: Antiooxidants, chitosan, hydrogels, oral mucosatis, free radicals, functional materials
Abstract: Chitosan based novel occlusive bioadhesive system for prophylaxis and/or treatment of oral mucositis based on chitosan, suitable surfactants (Cetyl trimethylammonium bromide and Polyquaternium-1 (Polyquad®)) and Propolis ethanolic extract were developed and evaluated in this investigation. The positive synergy was observed combined the antifungal and antioxidant capacity of synthetic and natural biomaterials into functional biocompatible gel. The in vitro antioxidant capacity (free radical scavenging by ORAC and intrinsic reducing capacity by Folin-Ciocalteu Method) was quantified and the influence of antioxidant capacity of Propolis extract on the rate of release of nystatin, from chitosan based material was investigated. These copolymer systems are able to release the drug over several weeks and therefore may be useful as a drug carrier in the treatment of oral mucosatis.
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Cite this article as:
Tamara Perchyonok V., Zhang Shengmiao and Oberholzer Theunis, Alternative Chitosan Based Drug Delivery System to Fight Oral Mucositis: Synergy of Conventional and Bioactives Towards the Optimal Solution, Current Nanoscience 2012; 8 (4) . https://dx.doi.org/10.2174/157341312801784320
DOI https://dx.doi.org/10.2174/157341312801784320 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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