Abstract
Hydrogen peroxide (H2O2) has entrapped the abundant concern of numerous researchers in the cutting edge of chemistry, biology and medicine since it is thought to be associated with various biological and pathological conditions. Fluorescent probes are the promising tools for the detection and understanding of the physiological roles of H2O2, considering that they are able to provide spatial and temporal information about target biomolecules in living cells. Nevertheless, the existent fluorescent probes have low selectivity and sensitivity on discerning H2O2. This review would like to demonstrate a comprehensive examination on the design, recognition, and performance of state-of-the-art boronate-based fluorogenic switch for the detection of H2O2, a field in which remarkable improvements have been accomplished over the last decade.
Keywords: Hydrogen peroxide, Fluorescent probes, Boronate, pathological conditions, biomolecules, boronate-based fluorogenic, Reactive oxygen species (ROS), byproducts, hydroxyl radical, dichlorodihydrofluorescein
Current Medicinal Chemistry
Title:Boronate Can Be the Fluorogenic Switch for the Detection of Hydrogen Peroxide
Volume: 19 Issue: 21
Author(s): Wei Sun, Jiyong Wu, Jing Li, Hao Fang, Lupei Du and Minyong Li
Affiliation:
Keywords: Hydrogen peroxide, Fluorescent probes, Boronate, pathological conditions, biomolecules, boronate-based fluorogenic, Reactive oxygen species (ROS), byproducts, hydroxyl radical, dichlorodihydrofluorescein
Abstract: Hydrogen peroxide (H2O2) has entrapped the abundant concern of numerous researchers in the cutting edge of chemistry, biology and medicine since it is thought to be associated with various biological and pathological conditions. Fluorescent probes are the promising tools for the detection and understanding of the physiological roles of H2O2, considering that they are able to provide spatial and temporal information about target biomolecules in living cells. Nevertheless, the existent fluorescent probes have low selectivity and sensitivity on discerning H2O2. This review would like to demonstrate a comprehensive examination on the design, recognition, and performance of state-of-the-art boronate-based fluorogenic switch for the detection of H2O2, a field in which remarkable improvements have been accomplished over the last decade.
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Cite this article as:
Sun Wei, Wu Jiyong, Li Jing, Fang Hao, Du Lupei and Li Minyong, Boronate Can Be the Fluorogenic Switch for the Detection of Hydrogen Peroxide, Current Medicinal Chemistry 2012; 19 (21) . https://dx.doi.org/10.2174/092986712801323270
DOI https://dx.doi.org/10.2174/092986712801323270 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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