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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Boronate Can Be the Fluorogenic Switch for the Detection of Hydrogen Peroxide

Author(s): Wei Sun, Jiyong Wu, Jing Li, Hao Fang, Lupei Du and Minyong Li

Volume 19 , Issue 21 , 2012

Page: [3622 - 3634] Pages: 13

DOI: 10.2174/092986712801323270

Price: $65


Hydrogen peroxide (H2O2) has entrapped the abundant concern of numerous researchers in the cutting edge of chemistry, biology and medicine since it is thought to be associated with various biological and pathological conditions. Fluorescent probes are the promising tools for the detection and understanding of the physiological roles of H2O2, considering that they are able to provide spatial and temporal information about target biomolecules in living cells. Nevertheless, the existent fluorescent probes have low selectivity and sensitivity on discerning H2O2. This review would like to demonstrate a comprehensive examination on the design, recognition, and performance of state-of-the-art boronate-based fluorogenic switch for the detection of H2O2, a field in which remarkable improvements have been accomplished over the last decade.

Keywords: Hydrogen peroxide, Fluorescent probes, Boronate, pathological conditions, biomolecules, boronate-based fluorogenic, Reactive oxygen species (ROS), byproducts, hydroxyl radical, dichlorodihydrofluorescein

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