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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Aminoacyl-tRNA Synthetase Inhibitors As Potent Antibacterials

Author(s): P.-C Lv and H.-L. Zhu

Volume 19 , Issue 21 , 2012

Page: [3550 - 3563] Pages: 14

DOI: 10.2174/092986712801323199

Price: $65

Abstract

The emergence of bacterial strains with resistance to currently marketed antibacterial agents has spurred interest in the discovery of new antibacterial agents with novel modes of action. One set of potential novel targets are the family of bacterial aminoacyltRNA synthetases (AaRS). Aminoacyl-tRNA synthetases are the enzymes that catalyze the transfer of amino acids to their cognate tRNA. They play a pivotal role in protein biosynthesis and are necessary for growth and survival of all cells. Consequently, inhibition of these enzymes is an attractive target for antibacterial agents. In this review, we examine the latest developments and structure-activity relationship (SAR) analysis of aminoacyl-tRNA synthetases inhibitors, including methionyl-tRNA synthetase, isoleucyl-tRNA synthetase and phenylalanyl-tRNA synthetase inhibitors. It is expected that increasing knowledge of the SAR of aminoacyl-tRNA synthetase inhibitors will be beneficial to the rational design of new generation of antibiotics.

Keywords: Aminoacyl-tRNA synthetases (AaRS), antibacterial agents, methionyl-tRNA synthetase, isoleucyl-tRNA synthetase, phenylalanyl-tRNA synthetase inhibitors


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