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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Recent Advances in the Development of Selective CB2 Agonists as Promising Anti-Inflammatory Agents

Author(s): N. Leleu-Chavain, M. Body-Malapel, J. Spencer, P. Chavatte, P. Desreumaux and R. Millet

Volume 19 , Issue 21 , 2012

Page: [3457 - 3474] Pages: 18

DOI: 10.2174/092986712801323207

Price: $65


The high distribution of CB2 receptors in immune cells suggests their important role in the control of inflammation. Growing evidence offers this receptor as an attractive therapeutic target: CB2 selective agonists are able to modulate inflammation without triggering psychotropic effects. This review will summarize the literature on the implication of CB2 in inflammation and CB2 selective agonists with anti-inflammatory activity.

Keywords: cannabinoids, CB2 receptors, CB2 agonists, inflammation, anti-inflammatory agents, central nervous system inflammation, chronic inflammatory diseases, IBD, Crohn’s disease, ulcerative colitis, ischemia/reperfusion injury, aminoalkylindoles, tricyclic pyrazoles, morpholines, quinolones

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