Abstract
The cancer stem cell (CSC) hypothesis presents a fundamentally different paradigm for cancer treatment. CSCs reflect a small fraction of tumor initiating cells capable of sustained self-renewal and differentiation to form the heterogeneous tumor bulk. In order to cure cancer, it is necessary to eliminate cancer stem cells in addition to differentiated cancer cells to decrease metastasis, reduce recurrence, and improve patient survival. In this article, we review cancer stem cell signaling pathways, including Wnt, Hedgehog, and Notch, as well as interactions of CSCs with the tumor microenvironment. We also review methods to isolate CSCs and demonstrate therapeutic efficacy of natural products to modulate these signaling pathways for eliminating CSCs.
Keywords: Akt, cancer stem cell, hedgehog, HIF-1α, natural product, NF-κB, notch, Wnt signaling, tumor, metastasis
Current Drug Targets
Title:Targeting Cancer Stem Cells with Natural Products
Volume: 13 Issue: 8
Author(s): Joseph Burnett, Bryan Newman and Duxin Sun
Affiliation:
Keywords: Akt, cancer stem cell, hedgehog, HIF-1α, natural product, NF-κB, notch, Wnt signaling, tumor, metastasis
Abstract: The cancer stem cell (CSC) hypothesis presents a fundamentally different paradigm for cancer treatment. CSCs reflect a small fraction of tumor initiating cells capable of sustained self-renewal and differentiation to form the heterogeneous tumor bulk. In order to cure cancer, it is necessary to eliminate cancer stem cells in addition to differentiated cancer cells to decrease metastasis, reduce recurrence, and improve patient survival. In this article, we review cancer stem cell signaling pathways, including Wnt, Hedgehog, and Notch, as well as interactions of CSCs with the tumor microenvironment. We also review methods to isolate CSCs and demonstrate therapeutic efficacy of natural products to modulate these signaling pathways for eliminating CSCs.
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Cite this article as:
Burnett Joseph, Newman Bryan and Sun Duxin, Targeting Cancer Stem Cells with Natural Products, Current Drug Targets 2012; 13 (8) . https://dx.doi.org/10.2174/138945012802009062
DOI https://dx.doi.org/10.2174/138945012802009062 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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