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Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Acylhydrazide Schiff Bases: DPPH Radical and Superoxide Anion Scavengers

Author(s): Khalid Mohammed Khan, Muhammad Taha, Farzana Naz, Salman Siddiqui, Sajjad Ali, Fazal Rahim, Shahnaz Perveen and M. Iqbal Choudhary

Volume 8 , Issue 4 , 2012

Page: [705 - 710] Pages: 6

DOI: 10.2174/157340612801216111

Price: $65

Abstract

Acylhydrazide Schiff bases 1-27 were evaluated for their in vitro DPPH radical and superoxide anion scavenging activity. They showed a varying degree of DPPH radical scavenging activity with IC50 values between 31.25 - 473.59 µM. Compounds 8, 2, and 10 have IC50 values 31.25 ± 1.32, 34.40 ± 0.66, and 37.24 ± 0.4 µM, respectively. Standard npropylgallate showed an IC50 value 30.12 ± 0.27 µM. Acylhydrazides 1-27 exhibited in vitro superoxide anion scavenging activities with IC50 values in the range of 175.6 - 450.89 µM. Results demonstrated that acylhyrazides 8, 2, and 10 have DPPH scavenging activity, comparable to standard n-propyl gallate while acylhyrazides 1-27 were found to be less superoxide anion scavenging active than the standard n-propyl gallate (IC50 = 106.34 ± 1.6 µM).

Keywords: Acylhyrazide Schiff bases, DPPH scavenger, superoxide anion scavenger, antioxidant, chemotherapeutic agents, antifungal, antiproliferative properties, anticonvulsant, analgesic


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