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Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Preparation, Chemical and Electrical Characterizations of Lipid Nanoparticles Loaded with Dihydroxybenzophenone

Author(s): Hierrezuelo Jesus, Benavente Juana, Lopez–Romero Juan Manuel, Martinez de Yuso Maria del Valle and Rodriguez–Castellon Enrique

Volume 8 , Issue 4 , 2012

Page: [541 - 548] Pages: 8

DOI: 10.2174/157340612801216238

Price: $65

Abstract

Lipid nanoparticles loading the sunscreen 2,4-dihydroxybenzophenone (DHB-LNPs) have been prepared by high-pressure homogenization and ultrasound techniques. The combination of both methodologies improves the entrapment efficiency percentage reaching 95%. The morphology of the DHB-LNPs was studied with scanning electron microscopy (SEM) and atomic force microscopy (AFM), while the surface and interior chemical composition was analyzed by X-ray photoelectron spectroscopy (XPS) at different irradiation times. Conductivity of aqueous dispersions of the DHBLNPs was determined by impedance spectroscopy. A possible DHB-LNPs application related to drug release in a system simulating skin-properties is shown.

Keywords: Lipid nanoparticles, 2, 4-dihydroxybenzophenone, homogenizer, ultrasounds, SEM, XPS, impedance spectroscopy, photoelectron, atomic force microscopy


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