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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Progress in Syntheses of 3-n-Butylphthalide and Its Analogues

Author(s): Mo Jun Xiong and Zhong Hui Li

Volume 11, Issue 9, 2007

Page: [833 - 844] Pages: 12

DOI: 10.2174/138527207780831738

Price: $65


3-n-Butylphthalide (1) and its analogues, which are the main components in the volatile oil of celery as well as a wide range of umbelliferae and composite plants, have potential applications as hypotensive drugs because of their strong pharmacological activities, such as improving the microcirculatory system of mans brain, improving nervous function deficiency, antiasthma, anticonvulsion, inhibiting platelet aggregation, inhibiting prostaglandin (PG) F2a growth, enhancing blood flow volume, antitumorigenesis, hypotensive activity and so on, so the investigation on the syntheses and applications of them has attracted considerable attention. The significant synthetic methods of 3-n-butylphthalide and its analogues were summarized and discussed in this review and it is expected that it may be valuable for their further development and applications.

Keywords: Benzoyl Chloride, o-Bromobenzaldehyde, Enyne-Diyne System, Chiral Phthalide, 3-Butylidenephthalide

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