Abstract
After completion of the human genome, genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with cancer initiation and progression. Most of the studies identified SNPs that were located outside the coding region, and the odds ratios were too low to implement in clinical practice. Although the genome gives information about genome sequence and structure, the human epigenome provides functional aspects of the genome. Epigenome-wide association studies (EWAS) provide an opportunity to identify genome-wide epigenetic variants that are associated with cancer. However, there are problems and issues in implementing EWAS to establish an association between epigenetic profiles and cancer. Few challenges include selection and handling of samples, choice of population and sample size, accurate measurement of exposure, integrating data, and insufficient information about the role of repeat sequences. The current status of EWAS, challenges in the field, and their potential solutions are discussed in this article.
Keywords: Acetylation, biomarker, chromatin, environmental mutagens, epidemiology, epigenetics, histone acetyl transferase (HAT), histone, histone deacetylase (HDAC), histone code, imprinting, methylation, methyl transferase, mutagens, risk assessment, screening
Current Genomics
Title:Epigenome-Wide Association Studies (EWAS) in Cancer
Volume: 13 Issue: 4
Author(s): Mukesh Verma
Affiliation:
Keywords: Acetylation, biomarker, chromatin, environmental mutagens, epidemiology, epigenetics, histone acetyl transferase (HAT), histone, histone deacetylase (HDAC), histone code, imprinting, methylation, methyl transferase, mutagens, risk assessment, screening
Abstract: After completion of the human genome, genome-wide association studies were conducted to identify single nucleotide polymorphisms (SNPs) associated with cancer initiation and progression. Most of the studies identified SNPs that were located outside the coding region, and the odds ratios were too low to implement in clinical practice. Although the genome gives information about genome sequence and structure, the human epigenome provides functional aspects of the genome. Epigenome-wide association studies (EWAS) provide an opportunity to identify genome-wide epigenetic variants that are associated with cancer. However, there are problems and issues in implementing EWAS to establish an association between epigenetic profiles and cancer. Few challenges include selection and handling of samples, choice of population and sample size, accurate measurement of exposure, integrating data, and insufficient information about the role of repeat sequences. The current status of EWAS, challenges in the field, and their potential solutions are discussed in this article.
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Cite this article as:
Verma Mukesh, Epigenome-Wide Association Studies (EWAS) in Cancer, Current Genomics 2012; 13 (4) . https://dx.doi.org/10.2174/138920212800793294
DOI https://dx.doi.org/10.2174/138920212800793294 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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