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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Polysaccharide-Based Nanoparticles: A Versatile Platform for Drug Delivery and Biomedical Imaging

Author(s): G. Saravanakumar, D.-G. Jo and J. H. Park

Volume 19 , Issue 19 , 2012

Page: [3212 - 3229] Pages: 18

DOI: 10.2174/092986712800784658

Price: $65


Polysaccharide-based nanoparticles have attracted interest as carriers for imaging and therapeutic agents because of their unique physicochemical properties, including biocompatibility and biodegradability. In addition, the functional groups of the polysaccharide backbone allow facile chemical modification to develop nanoparticles with diverse structures. Some polysaccharides have the intrinsic ability to recognize specific cell types, facilitating the design of targeted-drug delivery systems through receptor-mediated endocytosis. The main objective of this review is to provide an overview of various polysaccharide-based nanoparticles and to highlight the recent efforts that have been made to improve the characteristics of polysaccharide-based nanoparticles for drug delivery and biomedical imaging.

Keywords: Chemical modification, drug delivery, imaging agents, nanoparticles, polysaccharides, Polysaccharide-based, therapeutic agents, physicochemical properties, biocompatibility, biodegradability

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