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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Drug Delivery to Inflammation Based on Nanoparticles Surface Decorated with Biomolecules

Author(s): B. Clares, M. A. Ruiz, V. Gallardo and J. L. Arias

Volume 19 , Issue 19 , 2012

Page: [3203 - 3211] Pages: 9

DOI: 10.2174/092986712800784676

Price: $65

Abstract

Anti-inflammatory molecules often display little affinity for inflamed tissues, leading to low accumulation into this site of action (and inefficiency), and high incidence of severe side effects. To face the problem, numerous strategies have been proposed, i.e., chemical modifications to the drug molecule, and engineering of drug nanocarriers. The later approach to the problem can result in optimized drug biodistribution and concentration into the target region, thus enhancing the anti-inflammatory effect while reducing the associated drug toxicity. Such nanoparticulate systems offer remarkable possibilities when they are made of biodegradable polymers, lipid-based structures, and/or inorganic particles. Recent advances in the field have been devoted to the optimization of the in vivo fate and effectiveness of these drug nanocarriers, e.g., passive targeting strategies based on the functionalization of nanoparticle surface with special biomolecules. In this contribution, we analyze the possibilities and future perspectives of nanoparticle therapy in inflammatory processes.

Keywords: Arthritis, enhanced permeation and retention effect, inflammation, ligand-mediated drug/gene delivery, nanoparticle, passive drug targeting, Anti-inflammatory molecules, inflamed tissues, drug nanocarriers


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