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Current Vascular Pharmacology

Editor-in-Chief

ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

Omega-3 Fatty Acids and HDL. How Do They Work in the Prevention of Cardiovascular Disease?

Author(s): Elena Burillo, Paula Martin-Fuentes, Rocio Mateo-Gallego, Lucia Baila-Rueda, Ana Cenarro, Emilio Ros and Fernando Civeira

Volume 10, Issue 4, 2012

Page: [432 - 441] Pages: 10

DOI: 10.2174/157016112800812845

Price: $65

Abstract

Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) from marine origin have been strongly associated with cardiovascular protection, even at low doses (< 1g/d). Despite the research performed in this promising area, basic aspects, such as the ideal doses and the mechanisms by which ω-3 PUFAs act, are not precisely defined. The best known biological property of ω-3 PUFAs is their hypotriglyceridemic effect, but other cardioprotective actions, such as reduction of arrhythmia susceptibility, antithrombotic, antiinflammatory and antioxidant effects, improvement of endothelial function, and delayed atherosclerosis development have received an increased interest in recent years. Some of these actions are also ascribable to high-density lipoproteins (HDL). Abundant epidemiological evidence links increasing HDL-cholesterol concentrations to cardiovascular protection. Recently, the protein cargo (proteome) of HDL particles has been attributed a key role in their functionality. In this review, we summarize the main effects of ω-3 PUFAs on HDL-cholesterol, HDL subfractions, and its main proteins, apolipoproteins (apo) AI and AII. The shared cardioprotective actions of ω-3 PUFAs and HDL are reviewed as well.

Keywords: Omega-3 PUFAs, high-density lipoprotein, eicosapentaenoic acid and docosahexaenoic acid, atherosclerosis, apolipoproteins, proteome, CVD, coagulation, fibrinolysis


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