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Current Molecular Pharmacology

Editor-in-Chief

ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

Anabolic Effects of Intermittent PTH on Osteoblasts

Author(s): Edward M. Greenfield

Volume 5 , Issue 2 , 2012

Page: [127 - 134] Pages: 8

DOI: 10.2174/1874467211205020127

Price: $65

Abstract

Intermittent parathyroid hormone (iPTH) is the only FDA-approved therapy for bone loss due to conditions such as osteoporosis that increases bone formation by osteoblasts; all other therapies approved for osteoporosis block bone resorption by osteoclasts. The anabolic effects of iPTH are likely due to a combination of multiple mechanisms, including induction of immediate-early genes, increased expression and/or activity of essential osteoblast transcription factors, and downregulation of anti-osteogenic proteins, such as sclerostin. In contrast, continuous administration of PTH induces bone loss primarily due to up-regulation of RANKL expression and inhibition of osteoprotegerin expression.

Keywords: Anabolic, immediate-early genes, osteoblast, osteoprotegerin, PTH, RANKL, sclerostin, transcription factors


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