Generic placeholder image

Current HIV Research


ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Modulation of HIV Transmission by Neisseria gonorrhoeae: Molecular and Immunological Aspects

Author(s): Gary A. Jarvis and Theresa L. Chang

Volume 10, Issue 3, 2012

Page: [211 - 217] Pages: 7

DOI: 10.2174/157016212800618138

Price: $65


Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in monocytes and modulate T cell activation. In vivo, an increase in the number of endocervical CD4+ T cells has been found in GC-infected women. Additionally, GC appears to modulate HIV-specific immune responses in HIV-exposed sex workers. Interestingly, in vitro, GC exhibits HIV enhancing or inhibitory effects depending on the HIV target cells. This review summarizes molecular and immunological aspects of the modulation of HIV infection and transmission by GC. Future studies using a multi-cellular system or in animal models will offer insight into the mechanisms by which GC increases HIV transmission.

Keywords: Neisseria gonorrhoea, GC-HIV co-infection, HIV transmission.

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy