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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

NaOH-Al2O3 Catalyzed Synthesis of 1, 3, 5-triarylpentane-1, 5-diones Derivatives Under Solvent-Free Condition and Crystal Structure of 3-(2’, 4’-dichlorophenyl)-1, 5-diphenylpentane-1, 5-dione

Author(s): Xianqiang Huang, Qiu Feng, Yanliang Sun, Qingpeng He, Yong Wang

Volume 9 , Issue 4 , 2012

Page: [280 - 286] Pages: 7

DOI: 10.2174/157017812800233732

Price: $65


An efficient procedure for rapidly synthesizing the 1,3,5-triarylpentane-1,5-diones compounds using aromatic aldehydes and aromatic ketones as starting materials by tandem aldol reactions/Michael additions under NaOH/Al2O3 and the solvent-free conditions has been described. All compounds were characterized by IR, 1H NMR and elemental analysis. Additionally, the crystal structure of 3-(2’,4’-dichlorophenyl)-1,5-diphenylpentane-1,5-dione was obtained and determined by X-ray single-crystal diffraction. The protocol offers several advantages such as a simple, eco-friendly procedure and mild reaction conditions.

Keywords: 3, 5-triarylpentane-1, NaOH/Al2O3, crystal structure, 5-diones, Green Chemistry, cyclohexenones, pyridines, multi-substituted cyclodipentanes, heterocyclic compounds, triarylpentane-1, 5-dione

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