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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

One-Pot Synthesis of Amidoalkyl Naphthols Using POCl3/Na2B4O7 as a Heterogeneous Catalyst

Author(s): Hadi Jafari, Hassan Moghanian

Volume 9 , Issue 4 , 2012

Page: [273 - 275] Pages: 3

DOI: 10.2174/157017812800233796

Price: $65

Abstract

A convenient and efficient procedure for the synthesis of 1-amidoalkyl-2-naphthols by condensation of β- naphthol, aldehydes and amid/urea in the presence of POCl3/ Na2B4O7 is described. This method offers several advantages including low cost and easy availability of the catalyst, environmentally friendly procedure and easy work-up under solvent-free conditions.

Keywords: 1-Amidoalkyl-2-naphthols, borax, multicomponent reactions, POCl3, HIV, protease inhibitors, Iodine, temperatures, biological screening, benzaldehyde


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