Abstract
Based on the relative ratios of di- and tri-nucleotides in the DNA sequences, the profiles of 164 genome sequences from 152 representative microbial organisms were computed. By comparing the profiles of the genomes and their substrings with length 500 bps, the fluctuations of the relative abundances of di- and tri-nucleotides of these genomic sequences were analyzed. A new method to discriminate the origins of orphan DNA sequences was proposed, and the origins of 17 uncultured bacterium sequences from a bacterial community in the human gut were postulated and discussed.
Keywords: Bacterial community, DNA sequences, genome, profile
Combinatorial Chemistry & High Throughput Screening
Title: Oligonucleotide Profiling for Discriminating Bacteria in Bacterial Communities
Volume: 10 Issue: 4
Author(s): Ping-An He and Li Xia
Affiliation:
Keywords: Bacterial community, DNA sequences, genome, profile
Abstract: Based on the relative ratios of di- and tri-nucleotides in the DNA sequences, the profiles of 164 genome sequences from 152 representative microbial organisms were computed. By comparing the profiles of the genomes and their substrings with length 500 bps, the fluctuations of the relative abundances of di- and tri-nucleotides of these genomic sequences were analyzed. A new method to discriminate the origins of orphan DNA sequences was proposed, and the origins of 17 uncultured bacterium sequences from a bacterial community in the human gut were postulated and discussed.
Export Options
About this article
Cite this article as:
He Ping-An and Xia Li, Oligonucleotide Profiling for Discriminating Bacteria in Bacterial Communities, Combinatorial Chemistry & High Throughput Screening 2007; 10 (4) . https://dx.doi.org/10.2174/138620707780636646
DOI https://dx.doi.org/10.2174/138620707780636646 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
subject Index To Volume 3
Current Drug Targets Biomarkers of Asthma: Recent Patents from 2009-2011
Recent Patents on Biomarkers Evaluation of the QuantiFERON®-TB Gold In-Tube Assay and Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in an Iranian Referral Hospital
Infectious Disorders - Drug Targets Coumarine Analogues with Antimycobacterial and Immunomodulatory Activity
Current Bioactive Compounds Inhibition of the Archaeal β-Class (Cab) and γ-Class (Cam) Carbonic Anhydrases
Current Topics in Medicinal Chemistry Anti-TNF and Pouch Surgery for Ulcerative Colitis: The Ones who Blame for More Complications?
Current Drug Targets HIV-Infected Patients and Liver Transplantation: Who, When and Why
Current HIV Research A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections
Current Pharmaceutical Design Structural Proteomics: Inferring Function from Protein Structure
Current Proteomics Epitope-Driven TB Vaccine Development: A Streamlined Approach Using Immuno-Informatics, ELISpot Assays, and HLA Transgenic Mice
Current Molecular Medicine Structure-Based Drug Discovery Accelerated by Many-Core Devices
Current Drug Targets An Insight into the Dermatological Applications of Neem: A Review on Traditional and Modern Aspect
Recent Advances in Anti-Infective Drug Discovery Oxazolidinone-containing Hybrids with Antibacterial Activity against Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA): A Mini-review
Current Topics in Medicinal Chemistry Identification and Characterization of a Novel Oligomeric Decaprenyl Diphosphate Synthase
Protein & Peptide Letters Editorial: Nanomedicines for the Treatment of Tuberculosis: Role of Nanocarriers and Functional Excipients
Recent Patents on Anti-Infective Drug Discovery Novel Benzylidenehydrazide-1,2,3-Triazole Conjugates as Antitubercular Agents: Synthesis and Molecular Docking
Mini-Reviews in Medicinal Chemistry Attack on the Scourge of Tuberculosis: Patented Drug Targets
Recent Patents on Anti-Infective Drug Discovery Thinking Outside the ‘Block’: Alternative Polymer Compositions for Micellar Drug Delivery
Current Topics in Medicinal Chemistry Mucosal Delivery of Vaccines: Role of Mucoadhesive/Biodegradable Polymers
Recent Patents on Drug Delivery & Formulation Editorial (Thematic Issue: Multi-Target Drug Discovery in Medicinal Chemistry: Current Status and Future Perspectives)
Mini-Reviews in Medicinal Chemistry