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Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)

Editor-in-Chief

ISSN (Print): 1871-5222
ISSN (Online): 1875-6115

Eight-Year Follow-Up of an Initial Case with NF-κB Decoy Oligodeoxynucleotide Transfection After Coronary Stent Implantation

Author(s): Jun-ichi Suzuki, Daisuke Tezuka, Ryuichi Morishita, Mitsuaki Isobe

Volume 12, Issue 1, 2012

Page: [40 - 42] Pages: 3

DOI: 10.2174/187152212799857664

Price: $65

Abstract

Background: Nuclear factor–kappa B (NF-kB) plays a pivotal role in vascular remodeling after percutaneous coronary intervention (PCI) with a stent implantation.

Methods and Results: This is the first clinical report to demonstrate the effect of NF-kB decoy oligodeoxynucleotide (ODN) on the prevention of restenosis after an eight-year observation period. We revealed that decoy ODN treatment suppressed neointimal formation in comparison to that without ODN transfected stent lesion in the same artery.

Conclusion: We showed the long-term usefulness of NF-kB decoy ODN transfer after PCI.

Keywords: CT, coronary intervention, gene therapy, nuclear factor–kappa B, oligodeoxynucleotide, restenosis, stents


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