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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Epimerization Free Synthesis of O-Acyl Isodipeptides Employing COMU

Author(s): M. Samarasimhareddy, Hosahalli P. Hemantha, Kuppanna Ananda and Vommina V. Sureshbabu

Volume 19 , Issue 4 , 2012

Page: [406 - 410] Pages: 5

DOI: 10.2174/092986612799789413

Price: $65


O-Acyl isodipeptides are prepared by coupling Boc-Ser/Thr-OBzl with Fmoc-Xaa-OH employing COMU, well known third generation peptide coupling agent. The reaction proceeds with high yield and the chemical homogeneity of the synthesized molecules were established via chiral HPLC analyses. The O-acyl isodipeptide units play crucial role in the success of ‘click peptide’ protocol employed for assembling ‘difficult sequence’ peptides.

Keywords: O-acyl isodipeptide, click peptide, difficult sequence, COMU, esterification

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