Abstract
DNA and RNA regions containing tracts of guanines can form very stable secondary structures called G-quadruplex (G4). Genomic sequences with the potential to form G4 (G4-motifs) are abundant across species. In all analyzed genomes G4 motifs are found near promoter regions and double strand break sites and at telomeres. Telomeres are very G-rich and prone for G4 formation. Therefore they are routinely used in in vitro and in vivo experiments to elucidate the function of G4 structures in telomere metabolism. Recently various labs demonstrated that telomere length maintenance is mediated via G4 structures. Telomere-binding proteins specifically bind to G4 structure and regulate this structure throughout the cell cycle.
Keywords: Ciliate, helicase, higher-order DNA structure, telomere-binding protein, genomes, chromosomal ends, DNA replication, intronic splicing, TEBPβ, phosphorylation
Current Pharmaceutical Design
Title:Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres
Volume: 18 Issue: 14
Author(s): Stefan A. Juranek and Katrin Paeschke
Affiliation:
Keywords: Ciliate, helicase, higher-order DNA structure, telomere-binding protein, genomes, chromosomal ends, DNA replication, intronic splicing, TEBPβ, phosphorylation
Abstract: DNA and RNA regions containing tracts of guanines can form very stable secondary structures called G-quadruplex (G4). Genomic sequences with the potential to form G4 (G4-motifs) are abundant across species. In all analyzed genomes G4 motifs are found near promoter regions and double strand break sites and at telomeres. Telomeres are very G-rich and prone for G4 formation. Therefore they are routinely used in in vitro and in vivo experiments to elucidate the function of G4 structures in telomere metabolism. Recently various labs demonstrated that telomere length maintenance is mediated via G4 structures. Telomere-binding proteins specifically bind to G4 structure and regulate this structure throughout the cell cycle.
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Cite this article as:
A. Juranek Stefan and Paeschke Katrin, Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres, Current Pharmaceutical Design 2012; 18 (14) . https://dx.doi.org/10.2174/138161212799958404
DOI https://dx.doi.org/10.2174/138161212799958404 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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