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Current Cardiology Reviews

Editor-in-Chief

ISSN (Print): 1573-403X
ISSN (Online): 1875-6557

Anthracycline Cardiotoxicity: Prevalence, Pathogenesis and Treatment

Author(s): Maria Volkova and Raymond Russell

Volume 7, Issue 4, 2011

Page: [214 - 220] Pages: 7

DOI: 10.2174/157340311799960645

Price: $65

Abstract

Anthracyclines, such as doxorubicin and idarubicin, remain an important class of chemotherapeutic agents. Unfortunately, their efficacy in treating cancer is limited by a cumulative dose-dependent cardiotoxicity, which can cause irreversible heart failure. In this review, we discuss the pathogenesis and incidence of anthracycline-induced cardiotoxicity as well as methods to detect, prevent and treat the condition.

Keywords: Left ventricular dysfunction, doxorubicin, oxidant stress.


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